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Combined effects of six cytokine gene polymorphisms and SNP-SNP interactions on hepatocellular carcinoma risk in Southern Guangxi, China.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2014

Bei Chun-Hua, Bai Hua, Yu Hong-Ping, Yang Yan, Liang Qing-Qing, Deng Ying-Ying, Tan Sheng-Kui, Qiu Xiao-Qiang

Abstract excerpt

Cytokine gene single nucleotide polymorphisms (SNPs) are involved in the genesis and progression of hepatocellular carcinoma (HCC). We hypothesized that combined effects of cytokine gene SNPs and SNP-SNP interactions are associated with HCC risk. Six SNPs in cytokine genes (IL-2, IFN-γ, IL-1β, IL-6, and IL-10) were genotyped in a study of 720 Chinese HCC cases and 784 cancer-free controls. Although none of these...

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PMID: 25169554
DOI: 10.7314/apjcp.2014.15.16.6961

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