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Article

Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics.

Arthritis research & therapy - 1 Jan 2014

Dennis Glynn, Holweg Cécile T J, Kummerfeld Sarah K, Choy David F, Setiadi A Francesca, Hackney Jason A, Haverty Peter M, Gilbert Houston, Lin Wei Yu, Diehl Lauri, Fischer S, Song An, Musselman David, Klearman Micki, Gabay Cem, Kavanaugh Arthur, Endres Judith, Fox David A, Martin Flavius, Townsend Michael J

Abstract excerpt

INTRODUCTION: Rheumatoid arthritis (RA) is a complex and clinically heterogeneous autoimmune disease. Currently, the relationship between pathogenic molecular drivers of disease in RA and therapeutic response is poorly understood. METHODS: We analyzed synovial tissue samples from two RA cohorts of 49 and 20 patients using a combination of global gene expression, histologic and cellular analyses, and analysis of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25167216
DOI: 10.1186/ar4555
PMCID: PMC4060385

Genes

CXCL13
ACR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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