Influence of estrogen receptor α polymorphisms on bone density in response to habitual exercise in Japanese postmenopausal women.

Abstract excerpt

Estrogen receptor α (ER α) is one of candidate genes for osteoporosis. This study examined the influence of ER α gene, PvuII, and XbaI genotypes on bone density of calcaneus in response to habitual exercise. ER α polymorphisms were detected using PvuII and XbaI restriction enzymes in 316 Japanese postmenopausal women. The bone density was significantly lower in the women carrying PP, pp, or xx genotype without...

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