Article
Influence of distinct asthma phenotypes on lung function following weight loss in the obese.
Respirology (Carlton, Vic.) - 1 Nov 2014
Chapman David G, Irvin Charles G, Kaminsky David A, Forgione Patrick M, Bates Jason H T, Dixon Anne E
Abstract excerpt
BACKGROUND AND OBJECTIVE: There appears to be two distinct clinical phenotypes of obese patients with asthma-those with early-onset asthma and high serum IgE (TH2-high), and those with late-onset asthma and low serum IgE (TH2-low). The aim of the present study was to determine in the two phenotypes of obese asthma the effect of weight loss on small airway function. METHODS: TH2-low (n = 8) and TH2-high (n = 5)...
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