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Article

Rationally designed treatment for metastatic colorectal cancer: current drug development strategies.

World journal of gastroenterology - 14 Aug 2014

Spiliopoulou Pavlina, Arkenau Hendrik-Tobias

Abstract excerpt

The therapeutic landscape of metastatic colorectal cancer (mCRC) has changed substantially with the emergence of new molecularly targeted agents (MTA) used as single agents or alongside standard chemotherapy. The use of these MTAs extended the overall survival of patients with mCRC to a level that current chemotherapeutics alone could not achieve. In addition, improvement in surgical techniques and ablation...

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Identifiers

PMID: 25132745
DOI: 10.3748/wjg.v20.i30.10288
PMCID: PMC4130836

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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