Article
The Dutch String-of-Pearls Stroke Study: protocol of a large prospective multicenter genetic cohort study.
International journal of stroke : official journal of the International Stroke Society - 1 Jan 2015
Nederkoorn Paul J, van Dijk Ewoud J, Koudstaal Peter J, Luijckx Gert-Jan, van Oostenbrugge Robert J, Visser Marieke C, Wermer Marieke J H, Ruigrok Ynte M, Algra Ale, Kappelle L Jaap
Abstract excerpt
BACKGROUND: In the last couple of years, genome-wide association studies have largely altered the scope in genetic research in diseases in which both environmental and genetic risk factors contribute to the disease. To date, the genetic risk loci identified in stroke have lagged behind those in other complex diseases, possibly because of the heterogeneity of stroke phenotypes. Sufficiently large cohorts with...
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