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Article

A presenilin 1 mutation in the first case of Alzheimer's disease: Revisited

14 Aug 2014

Abstract excerpt

BACKGROUND: Recently, a single point mutation in the presenilin 1 (PSEN1) gene of the first described Alzheimer's disease (AD) patient Auguste D was reported by Müller and co-workers. However, the sequencing results of the DNA from a 100-year-old tissue contained some uncertainties. METHODS: We heat extracted DNA from an original histological slice of Auguste D's brain and used nested polymerase chain reaction...

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PMID: 25130656
DOI: 10.1016/j.jalz.2014.06.005

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