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Article

Neuropathology of patients with preclinical or early clinical Alzheimer's disease with pathogenic PSEN1_p. L392V: Comparison of advanced siblings.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Mar 2024

Hata Yukiko, Nakase Mio, Ichimata Shojiro, Yoshida Koji, Nishida Naoki

Abstract excerpt

INTRODUCTION: Neuropathological investigation of presymptomatic or early symptomatic presenilin-1 (PSEN1) mutation carriers in familial Alzheimer's disease (AD) is extremely scarce. METHODS: We report the autopsy findings of brothers with familial AD. Case 1 is a 45-year-old man without obvious cognitive impairment, who committed suicide. Case 2 is a 57-year-old older brother of Case 1 with advanced AD symptoms,...

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PMID: 38215435
DOI: 10.1002/alz.13675
PMCID: PMC10984492

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