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Article

Alternative splicing in osteoclasts and Paget's disease of bone.

BMC medical genetics - 14 Aug 2014

Klinck Roscoe, Laberge Gino, Bisson Martine, McManus Stephen, Michou Laëtitia, Brown Jacques P, Roux Sophie

Abstract excerpt

BACKGROUND: Mutations in the SQSTM1/p62 gene have been reported in Paget's disease of bone (PDB), but they are not sufficient to induce the pagetic osteoclast (OC) phenotype. We hypothesized that specific RNA isoforms of OC-related genes may contribute to the overactivity of pagetic OCs, along wi...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25115182
DOI: 10.1186/s12881-014-0098-1
PMCID: PMC4143580

Genes

RHOT1
LGALS8
USP4
SQSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25115182-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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