Article
Total serum transforming growth factor-β1 is elevated in the entire spectrum of genetic aortic syndromes.
Clinical cardiology - 1 Nov 2014
Hillebrand Mathias, Millot Nathalie, Sheikhzadeh Sara, Rybczynski Meike, Gerth Sabine, Kölbel Tilo, Keyser Britta, Kutsche Kerstin, Robinson Peter N, Berger Jürgen, Mir Thomas S, Zeller Tanja, Blankenberg Stefan, von Kodolitsch Yskert, Goldmann Britta
Abstract excerpt
BACKGROUND: Total serum transforming growth factor-beta 1 (tsTGF-β1) is increased in patients with Marfan syndrome (MFS), but it has not been assessed in thoracic aortic aneurysm and dissection (TAAD), Loeys-Dietz syndrome (LDS), and bicuspid aortic valve disease (BAVD). HYPOTHESIS: tsTGF-β1 is increased in genetic aortic syndromes including TAAD, LDS, MFS, and BAVD. METHODS: We measured tsTGF-β1 and performed...
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