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Article

Immune regulatory effects of panobinostat in patients with Hodgkin lymphoma through modulation of serum cytokine levels and T-cell PD1 expression

8 Aug 2014

Abstract excerpt

The Hodgkin Reed–Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL) are surrounded by a number of reactive and inflammatory cells. 1 The ability of HRS cells to evade immune surveillance is linked to a network of cytokines and chemokines that are produced by HRS and the surrounding cells, 1 , 2 , 3 in addition to the occasional aberrant expression of programmed death ligand-1 (PDL-1) by HRS 4 that inhibits...

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PMID: 25105535
DOI: 10.1038/bcj.2014.58

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