Article
PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors.
Breast cancer research : BCR - 8 Aug 2014
Lehmann Brian D, Bauer Joshua A, Schafer Johanna M, Pendleton Christopher S, Tang Luojia, Johnson Kimberly C, Chen Xi, Balko Justin M, Gómez Henry, Arteaga Carlos L, Mills Gordon B, Sanders Melinda E, Pietenpol Jennifer A
Abstract excerpt
INTRODUCTION: Triple negative breast cancer (TNBC) is a heterogeneous collection of biologically diverse cancers, which contributes to variable clinical outcomes. Previously, we identified a TNBC subtype that has a luminal phenotype and expresses the androgen receptor (AR+). TNBC cells derived from these luminal AR + tumors have high frequency phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha...
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