Article
Prediction of miRNA-mRNA associations in Alzheimer's disease mice using network topology.
BMC genomics - 3 Aug 2014
Noh Haneul, Park Charny, Park Soojun, Lee Young Seek, Cho Soo Young, Seo Hyemyung
Abstract excerpt
BACKGROUND: Little is known about the relationship between miRNA and mRNA expression in Alzheimer's disease (AD) at early- or late-symptomatic stages. Sequence-based target prediction algorithms and anti-correlation profiles have been applied to predict miRNA targets using omics data, but this approach often leads to false positive predictions. Here, we applied the joint profiling analysis of mRNA and miRNA...
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