Article
Atmospheric-pressure plasma jet induces DNA double-strand breaks that require a Rad51-mediated homologous recombination for repair in Saccharomyces cerevisiae.
Archives of biochemistry and biophysics - 15 Oct 2014
Lee Yoonna, Kim Kangil, Kang Kyu-Tae, Lee Jong-Soo, Yang Sang Sik, Chung Woo-Hyun
Abstract excerpt
Non-thermal plasma generated under atmospheric pressure produces a mixture of chemically reactive molecules and has been developed for a number of biomedical applications. Recently, plasma jet has been proposed as novel cancer therapies based on the observation that free radicals generated by plasma jet induce mitochondria-mediated apoptotic cell death. We show here that air plasma jet induces DNA double-strand...
Topics
- Atmospheric Pressure
- Cell Death
- DNA Breaks, Double-Stranded
- DNA Repair
- Homologous Recombination
- Mutagenesis
- Mutation
- Nitrogen
- Plasma Gases
- Rad51 Recombinase
- Reactive Nitrogen Species
- Reactive Oxygen Species
- Saccharomyces cerevisiae