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Article

Autophagy-preferential degradation of<i>MIR224</i>participates in hepatocellular carcinoma tumorigenesis

25 Jul 2014

Abstract excerpt

Autophagy and microRNA (miRNA) are important regulators during cancer cell tumorigenesis. Impaired autophagy and high expression of the oncogenic microRNA MIR224 are prevalent in hepatocellular carcinoma (HCC); however, the relationship between the 2 phenomena remains elusive. In this study, we are the first to reveal that autophagy selectively regulates MIR224 expression through an autophagosome-mediated...

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PMID: 25068270
DOI: 10.4161/auto.29959

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