Article
MUC1 expression in papillary thyroid carcinoma is associated with BRAF mutation and lymph node metastasis; the latter is the most important risk factor of relapse.
Thyroid : official journal of the American Thyroid Association - 1 Sept 2014
Renaud Florence, Gnemmi Viviane, Devos Patrick, Aubert Sébastien, Crépin Michel, Coppin Lucie, Ramdane Nassima, Bouchindhomme Brigitte, d'Herbomez Michelle, Van Seuningen Isabelle, Do Cao Christine, Pattou François, Carnaille Bruno, Pigny Pascal, Wémeau Jean-Louis, Leteurtre Emmanuelle
Abstract excerpt
BACKGROUND: The incidence of papillary thyroid carcinoma (PTC) has increased over the past 30 years in Western countries. PTC is usually associated with a good prognosis, but there is a wide range of aggressiveness, and some patients develop distant metastasis and/or resistance to standard treatment. Early identification of these high-risk tumors is a current challenge for appropriate patient management. MUC1...
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