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Article

β-Catenin inactivation is a pre-requisite for chick retina regeneration.

PloS one - 1 Jan 2014

Zhu Jie, Luz-Madrigal Agustin, Haynes Tracy, Zavada Julia, Burke Amy K, Del Rio-Tsonis Katia

Abstract excerpt

In the present study we explored the role of β-catenin in mediating chick retina regeneration. The chick can regenerate its retina by activating stem/progenitor cells present in the ciliary margin (CM) of the eye or via transdifferentiation of the retinal pigmented epithelium (RPE). Both modes require fibroblast growth factor 2 (FGF2). We observed, by immunohistochemistry, dynamic changes of nuclear β-catenin in...

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Source

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Identifiers

PMID: 25003522
DOI: 10.1371/journal.pone.0101748
PMCID: PMC4086939

Genes

RPE
FGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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