Article
Comparative effectiveness of next generation genomic sequencing for disease diagnosis: design of a randomized controlled trial in patients with colorectal cancer/polyposis syndromes.
Contemporary clinical trials - 1 Sept 2014
Gallego Carlos J, Bennette Caroline S, Heagerty Patrick, Comstock Bryan, Horike-Pyne Martha, Hisama Fuki, Amendola Laura M, Bennett Robin L, Dorschner Michael O, Tarczy-Hornoch Peter, Grady William M, Fullerton S Malia, Trinidad Susan B, Regier Dean A, Nickerson Deborah A, Burke Wylie, Patrick Donald L, Jarvik Gail P, Veenstra David L
Abstract excerpt
Whole exome and whole genome sequencing are applications of next generation sequencing transforming clinical care, but there is little evidence whether these tests improve patient outcomes or if they are cost effective compared to current standard of care. These gaps in knowledge can be addressed...
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