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Article

Well-differentiated thyroid cancer with a minor poorly differentiated component: clonal heterogeneity through the prognostic role of CXCR4 and BRAF analysis.

Applied immunohistochemistry & molecular morphology : AIMM - 1 Mar 2015

Rossi Esther D, Martini Maurizio, Capodimonti Sara, Straccia Patrizia, Revelli Luca, Lombardi Celestino P, Pontecorvi Alfredo, Santeusanio Giuseppe, Larocca Luigi M, Fadda Guido

Abstract excerpt

Well-differentiated carcinoma (WDC) accounts for up to 90% of all thyroid cancers. The presence of a minor poorly differentiated (PD) component (mainly insular pattern) might represent an additional critical parameter for patients' prognosis and outcome. The role of both CXCR4 (a chemokine inducing cytoskeletal rearrangement and cell adhesion) and BRAF mutation have been studied in WDC (mainly papillary thyroid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24992171
DOI: 10.1097/PAI.0000000000000083

Genes

CXCR4
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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