Article
Non-small cell lung cancer patients with EML4-ALK fusion gene are insensitive to cytotoxic chemotherapy.
Anticancer research - 1 Jul 2014
Morodomi Yosuke, Takenoyama Mitsuhiro, Inamasu Eiko, Toyozawa Ryo, Kojo Miyako, Toyokawa Gouji, Shiraishi Yoshimasa, Takenaka Tomoyoshi, Hirai Fumihiko, Yamaguchi Masafumi, Taguchi Kenichi, Seto Takashi, Sugio Kenji, Ichinose Yukito
Abstract excerpt
BACKGROUND: Although patients with the echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase gene (EML4-ALK) re-arrangement and epidermal growth factor gene EGFR mutations have proven sensitive to specific inhibitors, there is currently no consensus regarding the sensitivity of non-small cell lung cancer (NSCLC) patients with such mutations to cytotoxic chemotherapy. PATIENTS AND METHODS:...
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