Article
Rare co-existence of mutation in KRAS and ALK gene re-arrangement in an adenocarcinoma patient--a case report.
Anticancer research - 1 Jul 2014
Homa Iwona, Sawicki Marek, Wojas-Krawczyk Kamila, Nicoś Marcin, Mlak Radosław, Powrózek Tomasz, Krawczyk Paweł, Przybylski Piotr, Czekajska-Chehab Elżbieta, Milanowski Janusz
Abstract excerpt
Anaplastic lymphoma kinase (ALK) gene re-arrangements are present in approximately 4% of patients with non-small cell lung cancer (NSCLC), mostly in non-smokers with adenocarcinoma. V-KI-RAS2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations are more common in smokers. These molecular lesions were usually described as are mutually exclusive. We herein describe a rare case of co-existence of ALK and KRAS...
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