Clinical and genetic features of rhabdoid tumors of the heart registered with the European Rhabdoid Registry (EU-RHAB).

doi:10.1016/j.cancergen.2014.04.005

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Clinical and genetic features of rhabdoid tumors of the heart registered with the European Rhabdoid Registry (EU-RHAB).

Cancer genetics - 1 Sept 2014

Bartelheim Kerstin, Sumerauer David, Behrends Uta, Kodetova Daniela, Kucera Filip, Leuschner Ivo, Neumayer Petra, Oyen Florian, Rübe Christian, Siebert Reiner, Schneppenheim Reinhard, Seeringer Angela, Vasovcak Peter, Frühwald Michael C

Abstract excerpt

Rhabdoid tumors are rare but highly aggressive malignancies of infancy and early childhood with a generally unfavorable prognosis. Despite a wide variety of anatomic locations rhabdoid tumors share mutational inactivation of the SWI/SNF (SWItch/Sucrose NonFermentable) core component gene SMARCB1 (also known as INI1, hSNF5 or BAF47) in chromosome 22. As this inactivation usually results in loss of SMARCB1...

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Clinical and genetic features of rhabdoid tumors of the heart registered with the European Rhabdoid Registry (EU-RHAB).

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