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Article

Enrichment of MTHFR 677 T in a Chinese long-lived cohort and its association with lipid modulation.

Lipids in health and disease - 26 Jun 2014

Chen Ning-Yuan, Liu Cheng-Wu, Du Li-Li, Xiao Li-Ping, Ge Lin, Wang Yi-Yuan, Wei Zhen, Wu Hua-Yu, Luo Chen-Yuan, Liang Liang, Peng Jun-Hua, Luo Xiao-Qiu, Yin Rui-Xing, Nguyen Cuc Phuong, Pan Shang-Ling

Abstract excerpt

BACKGROUND: Variants in the Methylenetetrahydrofolate reductase (MTHFR) gene may result in a lowered catalytic activity and associate with subsequent elevated serum homocysteine (Hcy) concentration, abnormal DNA synthesis and methylation, cardiovascular risk, and unhealthy aging. Several investigations on the relationship of MTHFR C677T polymorphism with serum lipid profile and longevity have been conducted in...

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Identifiers

PMID: 24968810
DOI: 10.1186/1476-511X-13-104
PMCID: PMC4092207

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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