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Article

Activated janus kinase 3 expression not by activating mutations identified in natural killer/T-cell lymphoma.

Pathology international - 1 Jun 2014

Guo Ying, Arakawa Fumiko, Miyoshi Hiroaki, Niino Daisuke, Kawano Riko, Ohshima Koichi

Abstract excerpt

Janus Kinase 3 (JAK3) is a non-receptor tyrosine kinase, predominantly expressed in hematopoietic cells, that plays an essential role in hematopoiesis during T cell development. JAK3 somatic-activating mutations were identified in extranodal natural killer/T cell lymphomas (ENKTL) in recent cases in Singapore. We hypothesized these mutations might play an important role in the pathogenesis of T and NK cell...

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Identifiers

PMID: 24965108
DOI: 10.1111/pin.12166

Genes

JAK3

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