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Development to Term of Cloned Cattle Derived from Donor Cells Treated with Valproic Acid

24 Jun 2014

Abstract excerpt

Cloning of mammals by somatic cell nuclear transfer (SCNT) is still plagued by low efficiency. The epigenetic modifications established during cellular differentiation are a major factor determining this low efficiency as they act as epigenetic barriers restricting reprogramming of somatic nuclei. In this regard, most factors that promote chromatin decondensation, including histone deacetylase inhibitors...

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PMID: 24959750
DOI: 10.1371/journal.pone.0101022

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