Autophagy and human disease: emerging themes.

Abstract excerpt

Malfunction of autophagy, the process that mediates breakdown and recycling of intracellular components in lysosomes, has been linked to a variety of human diseases. As the number of pathologies associated with defective autophagy increases, emphasis has switched from the mere description of the status of autophagy in these conditions to a more mechanistic dissection of the autophagic changes. Understanding the...

Topics

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• Autophagy
• Lysosomal Storage Diseases
• Lysosomes
• Models, Biological
• Mutant Proteins
• Neurodegenerative Diseases