Article
Aicardi-Goutières syndrome harbours abundant systemic and brain-reactive autoantibodies.
Annals of the rheumatic diseases - 1 Oct 2015
Cuadrado Eloy, Vanderver Adeline, Brown Kristy J, Sandza Annie, Takanohashi Asako, Jansen Machiel H, Anink Jasper, Herron Brian, Orcesi Simona, Olivieri Ivana, Rice Gillian I, Aronica Eleonora, Lebon Pierre, Crow Yanick J, Hol Elly M, Kuijpers Taco W
Abstract excerpt
OBJECTIVES: Aicardi-Goutières syndrome (AGS) is an autoimmune disorder that shares similarities with systemic lupus erythematous. AGS inflammatory responses specially target the cerebral white matter. However, it remains uncertain why the brain is the most affected organ, and little is known about the presence of autoantibodies in AGS. Here, we aim to profile specific autoantibodies in AGS and to determine...
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