Article
Phenotype standardization for statin-induced myotoxicity.
Clinical pharmacology and therapeutics - 1 Oct 2014
Alfirevic A, Neely D, Armitage J, Chinoy H, Cooper R G, Laaksonen R, Carr D F, Bloch K M, Fahy J, Hanson A, Yue Q-Y, Wadelius M, Maitland-van Der Zee A H, Voora D, Psaty B M, Palmer C N A, Pirmohamed M
Abstract excerpt
Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis. Research in this area has been hampered to some extent by the lack of standardized nomenclature and phenotypic definitions. We have used numerical and descriptive classifications and developed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.