Article
Acute myeloid leukemia concurrent with spinal epidural extramedullary myeloid sarcoma accompanied by a high CD25 expression and the FLT3-ITD mutation.
Internal medicine (Tokyo, Japan) - 1 Jan 2014
Isshiki Yusuke, Ohwada Chikako, Togasaki Emi, Shimizu Ryoh, Hasegawa Nagisa, Yamazaki Atsuko, Sugita Yasumasa, Kawaguchi Takeharu, Tsukamoto Shokichi, Sakai Shio, Takeda Yusuke, Takeuchi Masahiro, Sakaida Emiko, Shimizu Naomi, Ota Satoshi, Yokote Koutaro, Iseki Tohru, Nakaseko Chiaki
Abstract excerpt
Myeloid sarcoma (MS) is an extramedullary myeloid tumor that sometimes presents with antedating systemic leukemia, leading physicians to the misdiagnosis of lymphoma. CD25 is expressed in 13% of patients with acute myeloid leukemia (AML), and its expression is associated with FLT3-ITD mutations, an elevated serum soluble interleukin 2 receptor (sIL-2R) level and a lower survival rate. However, there are no...
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