Article
HOXA1 Mutations are Not Commonly Associated with Non-Syndromic Deafness.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques - 1 Jul 2014
Abu-Amero Khaled K, Hagr Abdulrahman al, Almomani Murad O, Azad Taif Anwar, Alorainy Ibrahim A, Oystreck Darren T, Bosley Thomas M
Abstract excerpt
OBJECTIVE: Homozygous homeobox A1 (HOXA1) mutations cause a spectrum of abnormalities in humans including bilateral profound deafness. This study evaluates the possible role of HOXA1 mutations in familial, non-syndromic sensorineural deafness. METHODS: Forty-eight unrelated Middle Eastern families with either consanguinity or familial deafness were identified in a large deafness clinic, and the proband from each...
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