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Article

Stable long-term mixed chimerism achieved in a canine model of allogeneic in utero hematopoietic cell transplantation

29 May 2014

Abstract excerpt

Evidence supporting the efficacy of in utero hematopoietic cell transplantation (IUHCT) in a valid large animal model is needed prior to clinical application. The objective of this study was to establish clinically relevant levels of hematopoietic chimerism in a canine model of maternal-to-fetal IUHCT. We first assessed immune and hematopoietic ontogeny relevant to IUHCT in the canine model and identified 40...

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PMID: 24869940
DOI: 10.1182/blood-2013-11-537571

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