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TNFα induced by DNA-sensing in macrophage compromises retinal pigment epithelial (RPE) barrier function

2 Sept 2023

Abstract excerpt

Increasing evidence suggests that chronic inflammation plays an important role in the pathogenesis of age-related macular degeneration (AMD); however, the precise pathogenic stressors and sensors, and their impact on disease progression remain unclear. Several studies have demonstrated that type I interferon (IFN) response is activated in the retinal pigment epithelium (RPE) of AMD patients. Previously, we...

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PMID: 37660150
DOI: 10.1038/s41598-023-41610-7

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