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Article

Modeling of hemophilia A using patient-specific induced pluripotent stem cells derived from urine cells.

Life sciences - 11 Jul 2014

Jia Bei, Chen Shen, Zhao Zhiju, Liu Pengfei, Cai Jinglei, Qin Dajiang, Du Juan, Wu Changwei, Chen Qianyu, Cai Xiujuan, Zhang Hui, Yu Yanhong, Pei Duanqing, Zhong Mei, Pan Guangjin

Abstract excerpt

AIMS: Hemophilia A (HA) is a severe, congenital bleeding disorder caused by the deficiency of clotting factor VIII (FVIII). For years, traditional laboratory animals have been used to study HA and its therapies, although animal models may not entirely mirror the human pathophysiology. Human induced pluripotent stem cells (iPSCs) can undergo unlimited self-renewal and differentiate into all cell types. This study...

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Source

Identifiers

PMID: 24834837
DOI: 10.1016/j.lfs.2014.05.004

Genes

KLF4
SOX2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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