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Article

Generation of iPSC line from urine cells of hemophilia A with F8 (p. R814X) mutation.

Stem cell research - 1 Apr 2022

Sun Wenwen, Hu Xuchen, Wang Lingyu, Ma Yanchun, Zhang Xialin, Zhang Ruijuan, Zhao Lidong, Ren Juan, Yang Linhua, Wang Gang

Abstract excerpt

The lack of coagulation factor VIII in patient with nonsense mutation hemophilia A leads to varying degrees of bleeding symptoms, and long-term use of alternative therapies can produce inhibitors that affect the efficacy. In this study, human induced pluripotent stem cells (iPSCs) of hemophilia A were generated by reprogramming of urine cells. Human urine cells (HUCs) were isolated by collecting patients'...

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Identifiers

PMID: 35123343
DOI: 10.1016/j.scr.2022.102682

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Generation of iPSC line from urine cells of hemophilia A with F8 (p. R814X) mutation.PMID 35123343Read ↗

Modeling of hemophilia A using patient-specific induced pluripotent stem cells derived from urine cells.Semantic proximity Read ↗

Generation of induced pluripotent stem cell GZLSL-i001-A derived from urine-derived cells of Hemophilia A patient with Inv22 mutation.Semantic proximity Read ↗

Generation of induced pluripotent stem cell, BCHSCTi001-A, derived from a Hemophilia A patient with F8 (p. R391C) mutation.Semantic proximity Read ↗

Genetic Correction and Hepatic Differentiation of Hemophilia B-specific Human Induced Pluripotent Stem Cells.Semantic proximity Read ↗

Generation of an mESC model with a human hemophilia B nonsense mutation via CRISPR/Cas9 technology.Semantic proximity Read ↗

Restoration of FVIII Function and Phenotypic Rescue in Hemophilia A Mice by Transplantation of MSCs Derived From F8-Modified iPSCsSemantic proximity Read ↗

Establishment of a human induced pluripotent stem cell line (WMUi031-A) from a Lowe syndrome patient carrying a OCRL gene mutation (c.2626dupA).Semantic proximity Read ↗

Targeted inversion and reversion of the blood coagulation factor 8 gene in human iPS cells using TALENsSemantic proximity Read ↗

Generation of a human induced pluripotent stem cell line, YCMi002-A, from a Factor VII deficiency patient carrying F7 mutations.Semantic proximity Read ↗

Bioengineering hemophilia A-specific microvascular grafts for delivery of full-length factor VIII into the bloodstream.Semantic proximity Read ↗

ssODN-Mediated In-Frame Deletion with CRISPR/Cas9 Restores FVIII Function in Hemophilia A-Patient-Derived iPSCs and ECsSemantic proximity Read ↗

Generation of human induced pluripotent stem cell line (BCRTi007-A) from urinary cells of a patient with autosomal dominant polycystic kidney disease.Semantic proximity Read ↗

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