Cross-cancer pleiotropic analysis of endometrial cancer: PAGE and E2C2 consortia.

doi:10.1093/carcin/bgu107

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Cross-cancer pleiotropic analysis of endometrial cancer: PAGE and E2C2 consortia.

Carcinogenesis - 1 Sept 2014

Setiawan Veronica Wendy, Schumacher Fredrick, Prescott Jennifer, Haessler Jeffrey, Malinowski Jennifer, Wentzensen Nicolas, Yang Hannah, Chanock Stephen, Brinton Louise, Hartge Patricia, Lissowska Jolanta, Park S Lani, Cheng Iona, Bush William S, Crawford Dana C, Ursin Giske, Horn-Ross Pamela, Bernstein Leslie, Lu Lingeng, Risch Harvey, Yu Herbert, Sakoda Lori C, Doherty Jennifer, Chen Chu, Jackson Rebecca, Yasmeen Shagufta, Cote Michele, Kocarnik Jonathan M, Peters Ulrike, Kraft Peter, De Vivo Immaculata, Haiman Christopher A, Kooperberg Charles, Le Marchand Loic

Abstract excerpt

Genome-wide association studies (GWAS) have identified a large number of cancer-associated single nucleotide polymorphisms (SNPs), several of which have been associated with multiple cancer sites suggesting pleiotropic effects and shared biological mechanisms across some cancers. We hypothesized that SNPs associated with other cancers may be additionally associated with endometrial cancer. We examined 213 SNPs...

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PMID: 24832084
DOI: 10.1093/carcin/bgu107
PMCID: PMC4146418

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