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Article

Antisense-mediated FLC transcriptional repression requires the P-TEFb transcription elongation factor.

Proceedings of the National Academy of Sciences of the United States of America - 20 May 2014

Wang Zhi-Wei, Wu Zhe, Raitskin Oleg, Sun Qianwen, Dean Caroline

Abstract excerpt

The functional significance of noncoding transcripts is currently a major question in biology. We have been studying the function of a set of antisense transcripts called COOLAIR that encompass the whole transcription unit of the Arabidopsis floral repressor FLOWERING LOCUS C (FLC). Alternative polyadenylation of COOLAIR transcripts correlates with different FLC sense expression states. Suppressor mutagenesis...

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Identifiers

PMID: 24799695
DOI: 10.1073/pnas.1406635111
PMCID: PMC4034230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Antisense-mediated FLC transcriptional repression requires the P-TEFb transcription elongation factor.PMID 24799695Read ↗

Functional consequences of splicing of the antisense transcript COOLAIR on FLC transcription.Semantic proximity Read ↗

Cotranscriptional splicing is required in the cold to produce COOLAIR isoforms that repress Arabidopsis FLC.Semantic proximity Read ↗

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Cold-induced silencing by long antisense transcripts of an Arabidopsis Polycomb target.Semantic proximity Read ↗

The Arabidopsis RNA-binding protein FCA requires a lysine-specific demethylase 1 homolog to downregulate FLC.Semantic proximity Read ↗

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