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Article

Dissecting vancomycin-intermediate resistance in staphylococcus aureus using genome-wide association.

Genome biology and evolution - 30 Apr 2014

Alam Md Tauqeer, Petit Robert A, Crispell Emily K, Thornton Timothy A, Conneely Karen N, Jiang Yunxuan, Satola Sarah W, Read Timothy D

Abstract excerpt

Vancomycin-intermediate Staphylococcus aureus (VISA) is currently defined as having minimal inhibitory concentration (MIC) of 4-8 µg/ml. VISA evolves through changes in multiple genetic loci with at least 16 candidate genes identified in clinical and in vitro-selected VISA strains. We report a whole-genome comparative analysis of 49 vancomycin-sensitive S. aureus and 26 VISA strains. Resistance to vancomycin was...

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Identifiers

PMID: 24787619
DOI: 10.1093/gbe/evu092
PMCID: PMC4040999

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Source receipt: pubmed, retrieved 7 Sept 2026.

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