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Article

Gelsolin regulates cisplatin sensitivity in human head-and-neck cancer.

International journal of cancer - 15 Dec 2014

Wang Pei-Wen, Abedini Mohammad R, Yang Li-Xing, Ding Ann-Ann, Figeys Daniel, Chang Jang-Yang, Tsang Benjamin K, Shieh Dar-Bin

Abstract excerpt

Chemoresistance is a major challenge in cancer therapy. Cisplatin is commonly used for chemotherapy in patients with head-and-neck cancer (HNC), but it increases control of the disease by only 10-15%. Downregulation of proapoptotic pathways is a key determinant for chemoresistance in which gelsolin (GSN) is critically involved. We analyzed the association between GSN expression and cisplatin resistance in HNC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24771612
DOI: 10.1002/ijc.28928

Genes

GSN
XIAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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