Article
Standardized decision support in next generation sequencing reports of somatic cancer variants.
Molecular oncology - 1 Jul 2014
Dienstmann Rodrigo, Dong Fei, Borger Darrell, Dias-Santagata Dora, Ellisen Leif W, Le Long P, Iafrate A John
Abstract excerpt
Of hundreds to thousands of somatic mutations that exist in each cancer genome, a large number are unique and non-recurrent variants. Prioritizing genetic variants identified via next generation sequencing technologies remains a major challenge. Many such variants occur in tumor genes that have well-established biological and clinical relevance and are putative targets of molecular therapy, however, most variants...
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