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Article

CTC1 increases the radioresistance of human melanoma cells by inhibiting telomere shortening and apoptosis

2 Apr 2014

Abstract excerpt

Melanoma has traditionally been viewed as a radioresistant cancer. However, recent studies suggest that under certain clinical circumstances, radiotherapy may play a significant role in the treatment of melanoma. Previous studies have demonstrated that telomere length is a hallmark of radiosensitivity. The newly discovered mammalian CTC1‑STN1-TEN1 (CST) complex has been demonstrated to be an important telomere...

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PMID: 24718655
DOI: 10.3892/ijmm.2014.1721

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