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Article

A panel of phenotypically and genotypically diverse bioluminescent:fluorescent Trypanosoma cruzi strains as a resource for Chagas disease research.

PLoS neglected tropical diseases - 1 May 2024

Olmo Francisco, Jayawardhana Shiromani, Khan Archie A, Langston Harry C, Francisco Amanda Fortes, Atherton Richard L, Ward Alex I, Taylor Martin C, Kelly John M, Lewis Michael D

Abstract excerpt

Chagas disease is caused by Trypanosoma cruzi, a protozoan parasite that displays considerable genetic diversity. Infections result in a range of pathological outcomes, and different strains can exhibit a wide spectrum of anti-parasitic drug tolerance. The genetic determinants of infectivity, virulence and therapeutic susceptibility remain largely unknown. As experimental tools to address these issues, we have...

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PMID: 38820564
DOI: 10.1371/journal.pntd.0012106
PMCID: PMC11168640

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