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Article

Cellular aging of skeletal muscle: telomeric and free radical evidence that physical inactivity is responsible and not age

8 Apr 2014

Abstract excerpt

Telomeres play an essential role in maintaining chromosomal integrity in the face of physiological stressors. Although the age-related shortening of TL (telomere length) in highly proliferative tissue is predominantly due to the replication process, the mechanism for telomere shortening in skeletal muscle, which is minimally proliferative, is unclear. By studying TL in both the upper and lower limbs of the young,...

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Share to Genetics, Aging, and Longevity in Model Organisms
Share to Muscle Physiology and Disorders
Share to Telomeres, Telomerase, and Senescence

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Identifiers

PMID: 24708050
DOI: 10.1042/cs20140051

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