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Article

Implications of Differential Age Distribution of Disease-Associated Meningococcal Lineages for Vaccine Development

3 Apr 2014

Abstract excerpt

New vaccines targeting meningococci expressing serogroup B polysaccharide have been developed, with some being licensed in Europe. Coverage depends on the distribution of disease-associated genotypes, which may vary by age. It is well established that a small number of hyperinvasive lineages account for most disease, and these lineages are associated with particular antigens, including vaccine candidates. A...

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PMID: 24695776
DOI: 10.1128/cvi.00133-14

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