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Article

Sorafenib plus all-trans retinoic acid for AML patients with FLT3-ITD and NPM1 mutations.

European journal of haematology - 1 Dec 2014

Guenounou Sarah, Delabesse Eric, Récher Christian

Abstract excerpt

Knowledge of the molecular basis of acute myeloid leukaemia has increased considerably in the past few years, and therapies targeting specific molecular defects of this disease are intensively investigated. Patients with both NPM1 and FLT3-ITD mutations encompass 20% of cytogenetically normal AML. The multikinase and FLT3 inhibitor, sorafenib, has shown some efficacy in patients with relapsed FLT3-ITD(+) AML. In...

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Source

Identifiers

PMID: 24689895
DOI: 10.1111/ejh.12334

Genes

FLT3
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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