Age-associated differential microRNA levels in human follicular fluid reveal pathways potentially determining fertility and success of<b><i>in vitro</i></b>fertilization

Abstract excerpt

Reproductive life span and fertility have been shown to depend on successful early folliculogenesis, which involves cell-to-cell communication and the concerted regulation of gene expression at both the oocyte and granulosa cell levels. Recently, micro RNAs (miRNAs) were identified as fine-tuners of gene expression. Here, we report that miRNAs can readily be detected within membrane-enclosed vesicles of human...

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