Article
Analyses of the mitochondrial mutations in the Chinese patients with sporadic Creutzfeldt-Jakob disease.
European journal of human genetics : EJHG - 1 Jan 2015
Zhang Jin, Zhang Zhi-Xia, Du Peng-Chen, Zhou Wei, Wu Su-Dong, Wang Qi-Ling, Chen Cao, Shi Qi, Chen Chen, Gao Chen, Tian Chan, Dong Xiao-Ping
Abstract excerpt
Pathogenic mitochondrial DNA (mtDNA) mutations leading to mitochondrial dysfunction can cause a variety of chronic diseases in central nervous system (CNS). However, the role of mtDNA mutations in sporadic Creutzfeldt-Jakob disease (sCJD) has still been unknown. In this study, we comparatively analyzed complete mtDNA sequences of 31 Chinese sCJD patients and 32 controls. Using MITOMASTER and PhyloTree, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.