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A Promising DNA Methylation Signature for the Triage of High-Risk Human Papillomavirus DNA-Positive Women

19 Mar 2014

Abstract excerpt

High-risk human papillomavirus (hrHPV)-DNA testing is frequently performed parallel to cytology for the detection of high-grade dysplasia and cervical cancer particularly in women above 30 years of age. Although highly sensitive, hrHPV testing cannot distinguish between HPV-positive women with or without clinically relevant lesions. However, in principle discrimination is possible on the basis of DNA methylation...

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PMID: 24647315
DOI: 10.1371/journal.pone.0091905

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