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Article

HY Immune Tolerance Is Common in Women without Male Offspring

19 Mar 2014

Abstract excerpt

BACKGROUND: Sex difference is an established risk factor for hematopoietic stem cell transplantation (HSCT)-related complications like graft versus host disease (GVHD). CD8pos cytotoxic T cells specific for Y chromosome-encoded minor Histocompatibility antigens (HY) play an important role therein. Prior to HSC donation, female donors may encounter HY antigens through fetomaternal or transmaternal cell flow,...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Prenatal Screening and Diagnostics
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PMID: 24646895
DOI: 10.1371/journal.pone.0091274

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