Article
Her2 expression and gene amplification is rarely detectable in patients with oral squamous cell carcinomas.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Apr 2014
Hanken Henning, Gaudin Robert, Gröbe Alexander, Fraederich Meike, Eichhorn Wolfgang, Smeets Ralf, Simon Ronald, Sauter Guido, Grupp Katharina, Izbicki Jacob R, Sehner Susanne, Heiland Max, Blessmann Marco
Abstract excerpt
PURPOSE: Her2 (ErbB2) transforms cells when overexpressed and is an important therapeutic target in breast cancer. Contrary to breast cancer, studies on Her2 overexpression and gene amplification in squamous cell carcinomas of the head and neck region described largely different results. This study was undertaken to learn more on the prevalence and clinical significance of HER2 amplification and overexpression in...
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