Article
Compound HRAS/PIK3CA mutations in Chinese patients with alveolar rhabdomyosarcomas.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2014
Liu Chun-Xia, Li Xiao-Ying, Li Cheng-Fang, Chen Yun-Zhao, Cui Xiao-Bin, Hu Jian-Ming, Li Feng
Abstract excerpt
The rhabdomyosarcoma (RMS) is the most common type of soft tissue tumor in children and adolescents; yet only a few screens for oncogenic mutations have been conducted for RMS. To identify novel mutations and potential therapeutic targets, we conducted a high-throughput Sequenom mass spectrometry-based analysis of 238 known mutations in 19 oncogenes in 17 primary formalin-fixed paraffin-embedded RMS tissue...
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